49ers 2025 Opponents Meaning. Who do the san francisco 49ers play in the future? With week 16 in the books, we can project the 49ers’ 2025 schedule which looks on paper to be a much easier road than their 2024 slate.

For the 10th time, the san francisco 49ers found themselves on the losing end, a 40. Here’s what their 2025 opponents look like: